Acibroxi is an acetylcysteine effervescent tablet: it thins thick phlegm and makes coughing it up easier. It dissolves quickly in water. Order online.
Dosage form
Effervescent tablets.
Description
Smooth cylindrical tablets with a white score line, slight opacity is permissible, with a characteristic smell.
Composition
Acibroxi 200 mg
1 effervescent tablet contains:
Active substance: acetylcysteine 200 mg
Excipients: ascorbic acid, anhydrous sodium carbonate, sodium hydrogen carbonate, anhydrous citric acid, sorbitol, sodium citrate, macrogol 6000, sodium saccharin, “lemon” flavoring.
Acibroxi 600 mg
1 effervescent tablet contains:
Active substance: acetylcysteine 600 mg
Excipients: ascorbic acid, anhydrous sodium carbonate, sodium hydrogen carbonate, anhydrous citric acid, sorbitol, sodium citrate, macrogol 6000, sodium saccharin, “lemon” flavoring.
Pharmacotherapeutic group
Mucolytic agent, ATC code ღ05ჩB01.
Pharmacological properties
Pharmacodynamics
Acetylcysteine is a mucolytic, expectorant agent, a derivative of the amino acid cysteine. Thanks to the presence of a free sulfhydryl group, acetylcysteine breaks the bonds between the acid mucopolysaccharides of sputum, which causes depolymerization of mucoproteins and helps reduce the viscosity of bronchial secretions. Acetylcysteine shows mucolytic activity against any type of sputum: mucous, mucopurulent, purulent. It facilitates the discharge of sputum by increasing mucociliary clearance. Acetylcysteine can reduce the adhesion of bacteria to the epithelial cells of the bronchial mucosa, as a result of reducing sputum viscosity and increasing mucociliary clearance. Acetylcysteine also has antioxidant and pneumoprotective properties (which provide effective protection of the respiratory organs from the toxic effects of negative factors, such as: metabolites of inflammation, environmental factors, cigarette smoke, which is due to the ability of sulfhydryl groups to bind free radicals). In addition, acetylcysteine helps increase glutathione synthesis, which is an important factor in detoxification. This ability of acetylcysteine allows it to be used as an antidote in acute poisoning with paracetamol and other substances (aldehydes, phenols, etc.).
In this way, the functional activity and morphological integrity of the cells of lung tissues are preserved. The mucolytic properties of acetylcysteine begin to appear 1-2 days after the start of therapy. When used for prophylactic purposes, acetylcysteine reduces the frequency and severity of exacerbations of chronic bronchitis and cystic fibrosis
Indications for use
Diseases of the respiratory organs accompanied by increased production of viscous sputum that is difficult to clear:
Method of use and dosage
Acibroxi is taken orally.
One tablet containing 600 mg of acetylcysteine is dissolved in 200 ml of drinking water warmed to room temperature, or one tablet containing 200 mg of acetylcysteine is dissolved in 100 ml of drinking water warmed to room temperature.
The drug is taken after meals. Taking additional fluid enhances the mucolytic effect of acetylcysteine. It is taken immediately after dissolving; in exceptional cases the ready solution may be left for 2 hours.
