Brexin tab 20mg #20

International Nonproprietary Name:
Piroxicam

Composition:
Each tablet contains:

• Piroxicam beta-cyclodextrin (equivalent to 20 mg piroxicam).

Excipients:
Lactose monohydrate, crospovidone (type A), sodium starch glycolate (type A), hydrated colloidal silicon dioxide, pregelatinized starch, magnesium stearate.

Pharmacological Group:
Non-steroidal anti-inflammatory drug (NSAID).

Indications:
Used for relief of symptoms associated with:

• Osteoarthritis;
• Rheumatoid arthritis;
• Ankylosing spondylitis.

Due to its safety profile, piroxicam is not considered a first-line NSAID choice. Treatment should be based on an individual assessment of expected benefits and potential risks.

Dosage and Administration:
The dose is determined by a physician experienced in the treatment of inflammatory and degenerative rheumatic diseases.

Maximum recommended daily dose:

• 20 mg (1 tablet) once daily.

To reduce adverse effects, the lowest effective dose should be used for the shortest possible duration.

Contraindications:
Do not use in cases of:

• Hypersensitivity to piroxicam or any excipient;
• History of gastrointestinal bleeding or perforation;
• Active peptic ulcer;
• Ulcerative colitis, Crohn’s disease, diverticulitis, or gastrointestinal tumors;
• Severe renal or hepatic impairment;
• Moderate to severe heart disease;
• Severe hypertension;
• Blood disorders or hemorrhagic diathesis;
• Concomitant use with other NSAIDs, including selective COX-2 inhibitors;
• Concomitant use with anticoagulants;
• History of serious allergic reactions or severe skin reactions;
• Pregnancy and breastfeeding;
• Children.

Pregnancy and Lactation:
Piroxicam is contraindicated during pregnancy and breastfeeding.

In pregnancy, inhibition of prostaglandin synthesis may increase the risk of:

• Miscarriage;
• Fetal developmental abnormalities;
• Cardiovascular malformations.

During the third trimester of pregnancy, prostaglandin synthesis inhibitors may cause:

• Cardiovascular toxicity in the fetus;
• Renal dysfunction;
• Prolonged bleeding time;
• Delayed or prolonged labor.

Storage Conditions:
Store according to the instructions, in a dry place away from children.
The expiry date is indicated on the package.