Used for vulgar acne with comedones, papules, and pustules.
Contains 0.1% w/w adapalene, 0.2% w/w methylparaben, and 0.5% phenoxyethanol as preservatives.
Vulgar acne with comedones, papules, and pustules.
Adapalene is a chemically stable retinoid-like compound. Its biochemical and pharmacological profile is characterized by anti-inflammatory properties. Studies have shown that adapalene modulates cell differentiation, keratinization, and inflammatory processes, all of which are important in the pathogenesis of vulgar acne. Mechanistically, adapalene binds to specific nuclear retinoic acid receptors but does not bind to cytosolic receptor proteins. Although the exact mechanism is unknown, current evidence suggests that topical adapalene normalizes follicular epithelial cell differentiation, thereby reducing microcomedone formation.
Hypersensitivity to adapalene or any component of the product
Pregnancy (see pregnancy and lactation section)
Women planning pregnancy
After use, sensations of warmth, burning, itching, dryness, peeling, or tingling may occur. Additional side effects noted in about 1% or fewer patients include skin irritation, burning/tingling, erythema, sunburn, and acne-like rash. Most reactions develop within the first month of use and usually resolve with continued use or temporary discontinuation.
Pregnancy: Adequate and well-controlled studies in pregnant women have not been conducted. Adapalene should only be used during pregnancy if the potential benefit outweighs the potential risk to the fetus. Oral retinoids are associated with congenital anomalies. Topical retinoids result in low systemic exposure due to minimal absorption through the skin; however, individual factors (e.g., damaged skin barrier, excessive use) may lead to higher systemic exposure. T3 Ada Gel is contraindicated in pregnancy and in women planning pregnancy. Treatment should be discontinued if pregnancy occurs during use.
Lactation: It is unknown whether adapalene is excreted in breast milk. Since many drugs are excreted in breast milk, caution is advised when using T3 Ada Gel in breastfeeding women.
Apply a thin layer of the gel once daily in the evening after washing to the affected area. Avoid contact with eyes, lips, and mucous membranes. If necessary, the frequency of application can be reduced or temporarily stopped. Treatment can be resumed when the patient is able to tolerate it. If cosmetics are used concurrently, they should be non-comedogenic and non-astringent.
Keep the container tightly closed. Store at a temperature not exceeding 30°C.
