Lorista HD tablets 100/25mg #28 – Buy online. View price, description and delivery terms at PharmaDepot.
losartan, hydrochlorothiazide
Cardiovascular system → Antihypertensive agents → Combination products → Angiotensin II receptor antagonists combined with diuretics
Each tablet contains, in its core, the active substances losartan potassium 100 mg and hydrochlorothiazide 25 mg. The excipients include pregelatinized starch, microcrystalline cellulose, lactose monohydrate, and magnesium stearate. The film coating contains hypromellose, macrogol 4000, quinoline yellow (E104), titanium dioxide (E171), and salmond.
Oval, biconvex film-coated tablets with a yellowish or greenish tint.
Antihypertensive combination agent (angiotensin II receptor blocker + diuretic).
The medicine is indicated for the treatment of arterial hypertension in patients for whom combination therapy is appropriate. It is also used to reduce cardiovascular morbidity and mortality in patients with arterial hypertension and left ventricular hypertrophy.
The medicine is taken orally, regardless of food intake, and may be combined with other antihypertensive agents. In arterial hypertension, Lorista ND (100/25 mg) is usually prescribed as 1 tablet once daily, especially when Lorista H (50/12.5 mg) does not provide sufficient effect. The maximum antihypertensive effect is achieved within approximately 3 weeks. The maximum daily dose is 1 tablet once daily.
In patients with reduced circulating blood volume (for example, due to high doses of diuretics), the recommended initial dose of losartan is 25 mg once daily. In such cases, treatment should begin after discontinuation of diuretics and correction of hypovolemia.
In elderly patients and those with moderate renal impairment (creatinine clearance 30–50 mL/min, including patients on dialysis), no dose adjustment is required.
For cardiovascular risk reduction in patients with hypertension and left ventricular hypertrophy, the standard initial dose is 50 mg once daily. If blood pressure is not adequately controlled, therapy may be adjusted by combining losartan with low doses of hydrochlorothiazide. If necessary, the dose may be increased up to 100 mg losartan, and finally switched to Lorista ND 100/25 mg once daily.
The medicine is contraindicated in cases of hypersensitivity to losartan, hydrochlorothiazide, or any excipients, as well as hypersensitivity to sulfonamide derivatives. It must not be used in anuria, severe renal impairment (creatinine clearance < 30 mL/min), hyperkalemia, severe dehydration (including that caused by high-dose diuretics), severe hepatic impairment, refractory hypokalemia, pregnancy and lactation, arterial hypotension, age under 18 years, and in patients with lactase deficiency, galactosemia, or glucose-galactose malabsorption syndrome.
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